Leonard A Sauer Selected Research

13-hydroxy-9,11-octadecadienoic acid

10/2011	Circadian regulation of molecular, dietary, and metabolic signaling mechanisms of human breast cancer growth by the nocturnal melatonin signal and the consequences of its disruption by light at night.
8/2009	Antineoplastic effects of melatonin on a rare malignancy of mesenchymal origin: melatonin receptor-mediated inhibition of signal transduction, linoleic acid metabolism and growth in tissue-isolated human leiomyosarcoma xenografts.
10/2007	Dietary factors and growth and metabolism in experimental tumors.
5/2006	Human cancer xenograft perfusion in situ in rats: a new perfusion system that minimizes delivery time and maintains normal tissue physiology and responsiveness to growth-inhibitory agents.
1/2006	Dietary fish oil deactivates a growth-promoting signaling pathway in hepatoma 7288CTC in Buffalo rats.
12/2005	Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats.
9/2005	Eicosapentaenoic acid suppresses cell proliferation in MCF-7 human breast cancer xenografts in nude rats via a pertussis toxin-sensitive signal transduction pathway.
7/2005	Putting cancer to sleep at night: the neuroendocrine/circadian melatonin signal.
6/2004	Differential inhibition of fatty acid transport in tissue-isolated steroid receptor negative human breast cancer xenografts perfused in situ with isomers of conjugated linoleic acid.
6/2004	Melatonin uptake and growth prevention in rat hepatoma 7288CTC in response to dietary melatonin: melatonin receptor-mediated inhibition of tumor linoleic acid metabolism to the growth signaling molecule 13-hydroxyoctadecadienoic acid and the potential role of phytomelatonin.

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Leonard A Sauer Research Topics

Disease

18	Neoplasms (Cancer) 01/2021 - 02/2002
8	Breast Neoplasms (Breast Cancer) 01/2014 - 07/2002
6	Hepatocellular Carcinoma (Hepatoma) 01/2006 - 07/2002
2	Carcinogenesis 07/2005 - 06/2003
1	Squamous Cell Carcinoma of Head and Neck 01/2021
1	Prostatic Neoplasms (Prostate Cancer) 01/2021
1	Hyperglycemia 01/2014
1	Hyperinsulinism (Hyperinsulinemia) 01/2014
1	Sarcoma (Soft Tissue Sarcoma) 08/2009
1	Leiomyosarcoma 08/2009
1	Squamous Cell Neoplasms (Squamous Cell Cancer) 08/2007
1	Lipoma (Lipomata) 01/2006
1	Hyperlipidemias (Hyperlipidemia) 05/2003
1	Obesity 05/2003
1	Cachexia 05/2003
1	Adenocarcinoma 07/2002

Drug/Important Bio-Agent (IBA)

16	Linoleic Acid (Linoleate)IBA 01/2021 - 02/2002
13	MelatoninIBA 01/2021 - 02/2002
13	13-hydroxy-9,11-octadecadienoic acidIBA 10/2011 - 02/2002
10	Fatty Acids (Saturated Fatty Acids)IBA 08/2007 - 07/2002
8	ThymidineIBA 01/2021 - 06/2004
6	Melatonin Receptors (Melatonin Receptor)IBA 10/2011 - 02/2002
5	Eicosapentaenoic AcidIBA 01/2021 - 04/2003
5	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 06/2004
5	Conjugated Linoleic AcidsIBA 08/2007 - 04/2003
4	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 08/2009 - 08/2004
4	Pertussis ToxinIBA 01/2006 - 06/2004
3	Neurotransmitter Agents (Neurotransmitter)IBA 01/2021 - 04/2003
3	LipidsIBA 01/2014 - 05/2003
3	Mitogen-Activated Protein KinasesIBA 08/2009 - 02/2002
3	Corn Oil (Oil, Corn)IBA 08/2009 - 06/2004
3	Antineoplastic Agents (Antineoplastics)IBA 08/2009 - 02/2002
3	MitogensIBA 10/2007 - 06/2003
3	Biological ProductsIBA 12/2005 - 02/2002
2	hydroxyoctadecadienoic acidIBA 01/2021 - 08/2004
2	Fish OilsIBA 01/2021 - 01/2006
2	Hormones (Hormone)IBA 01/2014 - 06/2004
2	Adenosine Monophosphate (AMP)IBA 10/2011 - 01/2006
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 08/2009 - 08/2007
2	Dietary Fats (Dietary Fat)IBA 10/2007 - 09/2005
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 10/2007 - 04/2003
2	AcidsIBA 08/2007 - 01/2006
2	GTP-Binding Proteins (G-Protein)IBA 01/2006 - 08/2004
2	ErbB Receptors (EGF Receptor)IBA 07/2002 - 02/2002
1	Docosahexaenoic AcidsIBA 01/2021
1	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 01/2021
1	Estrogen ReceptorsIBA 10/2011
1	Estrogens (Estrogen)FDA Link 10/2011
1	Messenger RNA (mRNA)IBA 10/2011
1	Drinking WaterIBA 08/2009
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 10/2007
1	Linoleic AcidsIBA 08/2007
1	Olive OilIBA 01/2006
1	Trans Fatty AcidsIBA 08/2004
1	Steroid Receptors (Steroid Receptor)IBA 06/2004
1	Methylnitrosourea (N-Methyl-N-nitrosourea)IBA 07/2002
1	Cytostatic AgentsIBA 02/2002

Therapy/Procedure

1	Catheters 05/2006
1	Therapeutics 02/2002
1	Radiotherapy 02/2002